About Me

Hi! I'm Bobby Ranjan, a computer engineering student at Nanyang Technological University, Singapore. Born in Scotland, raised in India and studying in Singapore, I'm an ambitious student-researcher looking to enter the field of computational biology.

Education

Bachelor of Engineering (B.E.) in Computer Engineering with
Minors in Entrepreneurship & Life Sciences

2014 - 2018

Nanyang Technological University, Singapore

Publications

Composite Mathematical Modeling of Calcium Signaling behind Neuronal Cell Death in Alzheimer's Disease

April 2018
BMC Systems Biology - Volume 12 (The Sixteenth Asia-Pacific Bioinformatics Conference)

Background: Alzheimer's disease (AD) is a progressive neurological disorder, recognized as the most common cause of dementia affecting people aged 65 and above. AD is characterized by an increase in amyloid metabolism, and by the misfolding and deposition of β-amyloid oligomers in and around neurons in the brain. These processes remodel the calcium signaling mechanism in neurons, leading to cell death via apoptosis. Despite accumulating knowledge about the biological processes underlying AD, mathematical models to date are restricted to depicting only a small portion of the pathology.
Results: Here, we integrated multiple mathematical models to analyze and understand the relationship among amyloid depositions, calcium signaling and mitochondrial permeability transition pore(PTP)-related cell apoptosis in AD. The model was used to simulate calcium dynamics in the absence and presence of AD. In the absence of AD, i.e. without β-amyloid deposition, mitochondrial and cytosolic calcium level remains in the low resting concentration. However, our in silico simulation of the presence of AD with the β-amyloid deposition, shows an increase in the entry of calcium ions into the cell and dysregulation of Ca2+ channel receptors on the Endoplasmic Reticulum. This composite model enabled us to make simulation that is not possible to measure experimentally.
Conclusions: Our mathematical model depicting the mechanisms affecting calcium signaling in neurons can help understand AD at the systems level and has potential for diagnostic and therapeutic applications.

Experience

Software Design Engineer Intern

May - August 2017
BitTitan
  • Built customer-facing license consumption report for all BitTitan products
  • Conducted tech feasibility analysis to improve BitTitan’s reporting capacity
  • Built code analysis tool to clean up database references across codebase

Technology Analyst Intern

August - December 2016
Bank of America, Merrill Lynch (Singapore)
  • Worked on the payments processing and payments testing development teams
  • Redesigned database logging using a queueing mechanism with the help of Apache ActiveMQ and Java Spring Framework
  • Also built an application to help onboard new testers onto the testing platform, using Java, AngularJS and SQL

Summer Intern

May - July 2016
Asia Risk Transfer Solutions (ARTS), Singapore

Asia Risk Transfer Solutions - a software and technological solutions startup that aims to help the insurance industry and governments create and manage risk transfer products, known as Insurance for the Masses, for developing communities in Asia.

  • Worked in a small team of 6 on Android application development for the company
  • Developed 2 MVP Android applications for different user groups
  • Enhanced server-side API of the enterprise web application
  • Tech stack included Java, Android and Django

Projects

Protein Interaction Networks - A research project to modularise protein networks based on functionality using numerous module-detection algorithms.
ContextNewsBot - Context News Bot is a Chrome extension that allows you to step out of your filter bubble by providing a diverse set of news articles and objective Wikipedia entries for any tweet on your Twitter timeline.
CommandPlus - A Chrome extension that provides hand gesture-based control of one's browser.
CodeBot - An interactive chatbot that helps beginners learn how to code with witty replies, GIFs and human-readable errors.
When We Meet Again - An Android application that uses the relative distance between users, determined using the phone's Bluetooth, to trigger a reminder/push notification.
WhyBills - A system designed to eliminate printed bills at any point of sale by allowing retailers to encode their bill, generate a QR Code on our POS System and display this QR Code to the customer as a receipt.

Skills