Hi! I'm Bobby Ranjan, a bioinformatics specialist at the Genome Institute of Singapore. Born in Scotland, raised in India and working in Singapore, I'm an ambitious student-researcher in the field of computational biology.
Background: Alzheimer's disease (AD) is a progressive neurological disorder, recognized as the most common cause of dementia affecting people aged 65 and above. AD is characterized by an increase in amyloid metabolism, and by the misfolding and deposition of β-amyloid oligomers in and around neurons in the brain. These processes remodel the calcium signaling mechanism in neurons, leading to cell death via apoptosis. Despite accumulating knowledge about the biological processes underlying AD, mathematical models to date are restricted to depicting only a small portion of the pathology.
Results: Here, we integrated multiple mathematical models to analyze and understand the relationship among amyloid depositions, calcium signaling and mitochondrial permeability transition pore(PTP)-related cell apoptosis in AD. The model was used to simulate calcium dynamics in the absence and presence of AD. In the absence of AD, i.e. without β-amyloid deposition, mitochondrial and cytosolic calcium level remains in the low resting concentration. However, our in silico simulation of the presence of AD with the β-amyloid deposition, shows an increase in the entry of calcium ions into the cell and dysregulation of Ca2+ channel receptors on the Endoplasmic Reticulum. This composite model enabled us to make simulation that is not possible to measure experimentally.
Conclusions: Our mathematical model depicting the mechanisms affecting calcium signaling in neurons can help understand AD at the systems level and has potential for diagnostic and therapeutic applications.
- Working on identifying celltype populations in tumour single-cell RNA-sequencing data
- Built customer-facing license consumption report for all BitTitan products
- Conducted tech feasibility analysis to improve BitTitan’s reporting capacity
- Built code analysis tool to clean up database references across codebase
- Worked on the payments processing and payments testing development teams
- Redesigned database logging using a queueing mechanism with the help of Apache ActiveMQ and Java Spring Framework
- Also built an application to help onboard new testers onto the testing platform, using Java, AngularJS and SQL
Asia Risk Transfer Solutions - a software and technological solutions startup that aims to help the insurance industry and governments create and manage risk transfer products, known as Insurance for the Masses, for developing communities in Asia.
- Worked in a small team of 6 on Android application development for the company
- Developed 2 MVP Android applications for different user groups
- Enhanced server-side API of the enterprise web application
- Tech stack included Java, Android and Django